New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability
نویسندگان
چکیده
منابع مشابه
Peptergents: peptide detergents that improve stability and functionality of a membrane protein, glycerol-3-phosphate dehydrogenase.
Toward enhancing in vitro membrane protein studies, we have utilized small self-assembling peptides with detergent properties ("peptergents") to extract and stabilize the integral membrane flavoenzyme, glycerol-3-phosphate dehydrogenase (GlpD), and the soluble redox flavoenzyme, NADH peroxidase (Npx). GlpD is a six transmembrane spanning redox enzyme that catalyzes the oxidation of glycerol-3-p...
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N-d-Gluco-N-methylalkanamide detergents have been synthesized. The detergents, which were produced in high yield and at low cost, compared favourably in biochemical studies with commonly used non-ionic detergents, including a chemically related n-alkyl glucoside. The ease of removal by dialysis, high solubilizing power and non-denaturing properties of this new class of detergents make them valu...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2020
ISSN: 1554-8929,1554-8937
DOI: 10.1021/acschembio.0c00316